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Binding potential : ウィキペディア英語版
Binding potential
In pharmacokinetics and receptor-ligand kinetics the binding potential (BP) is a combined measure of the density of "available" neuroreceptors and the affinity of a drug to that neuroreceptor.
== Description ==
Consider a ligand receptor binding system. Ligand with a concentration ''L'' associates with a receptor of concentration or availability ''R'' to form a ligand-receptor complex with concentration ''RL''. The binding potential is then the ratio ligand-receptor complex to free ligand at equilibrium and in the limit of L tending to 0, and is given symbol BP:
BP=\frac\bigg|_
This quantity, originally defined by Mintun, describes the capacity of a receptor to bind ligand. It is a limit (L << Ki) of the general receptor association equation:
RL=\frac
and is thus also equivalent to:
BP=\frac
These equations apply equally when measuring the total receptor density or the residual receptor density available after binding to second ligand - availability.

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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